CDK9

CDK9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5
Identifiers
Aliases	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK, cyclin-dependent kinase 9, cyclin dependent kinase 9
External IDs	OMIM: 603251 MGI: 1328368 HomoloGene: 55566 GeneCards: CDK9
Targeted by Drug
dinaciclib, seliciclib
Gene ontology Molecular function • nucleotide binding • transferase activity • protein kinase activity • 7SK snRNA binding • transcription coactivator binding • snRNA binding • ATP binding • RNA polymerase II core promoter sequence-specific DNA binding • DNA binding • transcription factor binding • protein binding • protein serine/threonine kinase activity • chromatin binding • kinase activity • cyclin-dependent protein serine/threonine kinase activity • RNA polymerase II carboxy-terminal domain kinase activity • protein kinase binding • cyclin binding • transcription regulatory region DNA binding Cellular component • cytoplasm • nucleus • membrane • nucleoplasm • transcription elongation factor complex • cyclin/CDK positive transcription elongation factor complex • PML body • P-body • chromosome Biological process • positive regulation of cardiac muscle hypertrophy • positive regulation of mRNA 3'-UTR binding • regulation of muscle cell differentiation • negative regulation of mRNA polyadenylation • DNA repair • cellular response to cytokine stimulus • positive regulation of viral transcription • replication fork processing • protein phosphorylation • regulation of histone modification • regulation of mitotic cell cycle • cellular response to DNA damage stimulus • transcription initiation from RNA polymerase II promoter • negative regulation of cell cycle arrest • regulation of DNA repair • regulation of transcription, DNA-templated • cell proliferation • response to drug • transcription from RNA polymerase II promoter • phosphorylation • positive regulation of histone phosphorylation • positive regulation of histone H2B ubiquitination • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • snRNA transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • phosphorylation of RNA polymerase II C-terminal domain Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1025	107951
Ensembl	ENSG00000136807	ENSMUSG00000009555
UniProt	P50750	Q99J95
RefSeq (mRNA)	NM_001261	NM_130860
RefSeq (protein)	NP_001252 NP_001252.1	NP_570930.1 NP_570930
Location (UCSC)	Chr 9: 127.79 – 127.79 Mb	Chr 2: 32.71 – 32.71 Mb
PubMed search

3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5

1025

107951

ENSG00000136807

ENSMUSG00000009555

...
Wikipedia