CDC23

CDC23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	CDC23, ANAPC8, APC8, CUT23, cell division cycle 23
External IDs	MGI: 1098815 HomoloGene: 3426 GeneCards: CDC23
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding Cellular component • nucleoplasm • cytosol • intracellular • anaphase-promoting complex Biological process • ubiquitin-dependent protein catabolic process • regulation of exit from mitosis • regulation of mitotic metaphase/anaphase transition • cell cycle • cell division • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein K11-linked ubiquitination • metaphase/anaphase transition of mitotic cell cycle • anaphase-promoting complex-dependent catabolic process • protein ubiquitination • mitotic metaphase plate congression • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • mitotic cell cycle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8697	52563
Ensembl	ENSG00000094880	ENSMUSG00000024370
UniProt	Q9UJX2	Q8BGZ4
RefSeq (mRNA)	NM_004661	NM_178347
RefSeq (protein)	NP_004652	NP_848124
Location (UCSC)	Chr 5: 138.19 – 138.21 Mb	Chr 18: 34.63 – 34.65 Mb
PubMed search

4UI9, 5A31, 5G05, 5G04

8697

52563

ENSG00000094880

ENSMUSG00000024370

Q9UJX2

Q8BGZ4

NM_004661

NM_178347

NP_004652

NP_848124

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.

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