CD5 (protein)

CD5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JA4, 2JOP, 2JP0, 2OTT
Identifiers
Aliases	CD5, LEU1, T1, CD5 molecule
External IDs	OMIM: 153340 MGI: 88340 HomoloGene: 7260 GeneCards: CD5
Gene ontology Molecular function • scavenger receptor activity • protein binding • transmembrane signaling receptor activity • receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane • external side of plasma membrane Biological process • apoptotic signaling pathway • T cell costimulation • cell proliferation • cell recognition • receptor-mediated endocytosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	921	12507
Ensembl	ENSG00000110448	ENSMUSG00000024669
UniProt	P06127	P13379
RefSeq (mRNA)	NM_014207 NM_001346456	NM_007650
RefSeq (protein)	NP_001333385 NP_055022	NP_031676.3 NP_031676
Location (UCSC)	Chr 11: 61.1 – 61.13 Mb	Chr 19: 10.72 – 10.74 Mb
PubMed search

2JA4, 2JOP, 2JP0, 2OTT

921

12507

ENSG00000110448

ENSMUSG00000024669

P06127

P13379

NM_014207
NM_001346456

NM_007650

NP_001333385
NP_055022

NP_031676.3
NP_031676

CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. The expression of this receptor in human B cells has been a controversial topic and up to date there is no consensus regarding the role of this receptor as a marker of human B cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed.

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Wikipedia