CD3E

CD3E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A81, 1SY6, 1XIW, 2ROL
Identifiers
Aliases	CD3E, IMD18, T3E, TCRE, CD3e molecule
External IDs	MGI: 88332 HomoloGene: 586 GeneCards: CD3E
Gene ontology Molecular function • signal transducer activity, downstream of receptor • SH3 domain binding • signal transducer activity • protein binding • protein heterodimerization activity • receptor signaling complex scaffold activity • T cell receptor binding • protein kinase binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • cell-cell junction • alpha-beta T cell receptor complex • plasma membrane • integral component of plasma membrane • T cell receptor complex • immunological synapse • external side of plasma membrane Biological process • regulation of apoptotic process • G-protein coupled receptor signaling pathway • positive regulation of calcium-mediated signaling • negative regulation of smoothened signaling pathway • T cell differentiation in thymus • response to nutrient • protein complex assembly • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • T cell costimulation • positive regulation of interferon-gamma production • signal complex assembly • negative regulation of gene expression • positive regulation of interleukin-4 production • positive regulation of interleukin-2 biosynthetic process • negative thymic T cell selection • cell surface receptor signaling pathway • positive regulation of gene expression • positive regulation of T cell anergy • positive regulation of T cell activation • positive regulation of T cell proliferation • positive regulation of alpha-beta T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • regulation of immune response • apoptotic signaling pathway • lymphocyte activation • T cell receptor signaling pathway • T cell activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	916	12501
Ensembl	ENSG00000198851	ENSMUSG00000032093
UniProt	P07766	P22646
RefSeq (mRNA)	NM_000733	NM_007648
RefSeq (protein)	NP_000724	NP_031674.1 NP_031674
Location (UCSC)	Chr 11: 118.3 – 118.32 Mb	Chr 9: 45 – 45.01 Mb
PubMed search

1A81, 1SY6, 1XIW, 2ROL

916

12501

ENSG00000198851

ENSMUSG00000032093

P07766

P22646

NM_000733

NM_007648

NP_000724

NP_031674.1
NP_031674

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.

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Wikipedia