CD31

PECAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KY5, 5C14
Identifiers
Aliases	PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1
External IDs	OMIM: 173445 MGI: 97537 HomoloGene: 47925 GeneCards: PECAM1
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • platelet alpha granule membrane • membrane raft • cell junction • plasma membrane • extracellular exosome • membrane • extracellular space • secretory granule membrane Biological process • diapedesis • glomerular endothelium development • platelet degranulation • cell adhesion • extracellular matrix organization • cell recognition • leukocyte migration • signal transduction • phagocytosis • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5175	18613
Ensembl	ENSG00000261371	ENSMUSG00000020717
UniProt	P16284	Q08481
RefSeq (mRNA)	NM_000442	NM_001032378 NM_008816 NM_001305157 NM_001305158
RefSeq (protein)	NP_000433	NP_001027550.1 NP_001292086.1 NP_001292087.1 NP_032842.2 NP_001027550 NP_001292086 NP_001292087 NP_032842
Location (UCSC)	Chr 17: 64.32 – 64.41 Mb	Chr 11: 106.65 – 106.75 Mb
PubMed search

2KY5, 5C14

5175

18613

ENSG00000261371

ENSMUSG00000020717

P16284

Q08481

NM_000442

NM_001032378
NM_008816
NM_001305157
NM_001305158

NP_000433

NP_001292086
NP_001292087
NP_032842

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome 17. PECAM-1 plays a key role in removing aged neutrophils from the body.

PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte transmigration, angiogenesis, and integrin activation.

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Wikipedia