CCR8

Identifiers

CCR8, CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1, C-C motif chemokine receptor 8

External IDs

MGI: 1201402 HomoloGene: 21080 GeneCards: CCR8

Gene ontology
Molecular function	• C-C chemokine receptor activity • G-protein coupled receptor activity • chemokine receptor activity • coreceptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • membrane
Biological process	• positive regulation of cytosolic calcium ion concentration • chemotaxis • chemokine-mediated signaling pathway • G-protein coupled receptor signaling pathway • cell adhesion • immune response • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1237


12776

Ensembl


ENSG00000179934


ENSMUSG00000042262

UniProt


P51685


P56484

RefSeq (mRNA)


NM_005201


NM_007720

RefSeq (protein)


NP_005192


NP_031746.1 NP_031746

Location (UCSC)

Chr 3: 39.33 – 39.33 Mb

Chr 9: 120.09 – 120.09 Mb

PubMed search

NP_031746.1
NP_031746

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1. CCL8 also functions as a CCR8 agonist.

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.

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