CCKBR

CCKBR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L4T
Identifiers
Aliases	CCKBR, CCK-B, CCK2R, GASR, cholecystokinin B receptor
External IDs	MGI: 99479 HomoloGene: 7258 GeneCards: CCKBR
Targeted by Drug
sincalide, lorglumide
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • 1-phosphatidylinositol-3-kinase regulator activity • protein binding • cholecystokinin receptor activity • type B gastrin/cholecystokinin receptor binding • phosphatidylinositol phospholipase C activity • gastrin receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • sensory perception • gastric acid secretion • positive regulation of cytosolic calcium ion concentration • digestion • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • feeding behavior • positive regulation of cell proliferation • cell proliferation • digestive tract development • signal transduction • gland development • cholecystokinin signaling pathway • regulation of phosphatidylinositol 3-kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	887	12426
Ensembl	ENSG00000110148	ENSMUSG00000030898
UniProt	P32239	P56481
RefSeq (mRNA)	NM_176875 NM_001318029	NM_007627
RefSeq (protein)	NP_001304958 NP_795344	NP_031653.1 NP_031653
Location (UCSC)	Chr 11: 6.26 – 6.27 Mb	Chr 7: 105.43 – 105.47 Mb
PubMed search

1L4T

887

12426

ENSG00000110148

ENSMUSG00000030898

P32239

P56481

NM_176875
NM_001318029

NM_007627

NP_001304958
NP_795344

NP_031653.1
NP_031653

The cholecystokinin B receptor also known as CCKBR or CCK₂ is a protein that in humans is encoded by the CCKBR gene.

This gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.

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