CA-125

MUC16

Identifiers

MUC16, CA125, mucin 16, cell surface associated

External IDs

OMIM: 606154 HomoloGene: 133291 GeneCards: MUC16

Gene ontology
Molecular function	• protein binding
Cellular component	• Golgi lumen • integral component of membrane • extracellular region • vesicle • extracellular exosome • membrane • extrinsic component of membrane • extracellular space • plasma membrane
Biological process	• cell adhesion • O-glycan processing • stimulatory C-type lectin receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


94025


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Ensembl


ENSG00000181143


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UniProt


Q8WXI7


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RefSeq (mRNA)


NM_024690


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RefSeq (protein)


NP_078966


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Location (UCSC)

Chr 19: 8.85 – 8.98 Mb

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PubMed search

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CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other conditions that are benign.

Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain. A unique property of MUC16 is its large size. MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin.

MUC16 is composed of three different domains:

The N-terminal and tandem repeat domains are both entirely extracellular and highly O-glycosylated. All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and proline. The C-terminal domain contains multiple extracellular SEA (sea urchin sperm protein, enterokinase, and agrin) modules, a transmembrane domain, and a cytoplasmic tail. The extracellular region of MUC16 can be released from the cell surface by undergoing proteolytic cleavage. MUC16 is thought to be cleaved at a site in the SEA modules.

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Wikipedia