C-Met inhibitor

c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of (HGF/SF). These inhibitors may have therapeutic application in the treatment of various types of cancers.

Many c-Met inhibitors are currently in clinical trials. Crizotinib and Cabozantinib were the first to be approved by the U.S. FDA; Crizotinib received accelerated approval for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) that is ALK-positive as detected by a test approved by the U.S. Food and Drug Administration (FDA). Cabozantinib was approved in November 2012 for the treatment of medullary thyroid cancer and it has also started clinical trials for the treatment of prostate, bladder, ovarian, brain, melanoma, breast, non-small cell lung, pancreatic, hepatocellular and kidney cancers.

c-Met stimulates cell scattering, invasion, protection from apoptosis and angiogenesis. c-Met is a receptor tyrosine kinase, which can cause a wide variety of different cancers, such as renal, gastric and small cell lung carcinomas, central nervous system tumours, as well as several sarcomas when its activity is dysregulated. Targeting the ATP binding site of c-Met by small molecules inhibitors is one strategy for inhibition of the tyrosine kinase.

Early in the 1980‘s MET was described as the protein product of a transforming oncogene.

...
Wikipedia