The Vincennes Trace was a major trackway running through what are now the American states of Kentucky, Indiana, and Illinois. Originally formed by millions of migrating bison, the Trace crossed the Ohio River near the Falls of the Ohio and continued northwest to the Wabash River, near present-day Vincennes, before it crossed to what became known as Illinois. This buffalo migration route, often 12 to 20 feet wide in places, was well known and used by American Indians. Later European traders and American settlers learned of it, and many used it as an early land route to travel west into Indiana and Illinois. It is considered the most important of the traces to the Illinois country.
It was known by various names, including Buffalo Trace, Louisville Trace, Clarksville Trace, and Old Indian Road. After being improved as a turnpike, the New Albany-Paoli Pike, among others. The Trace's continuous use encouraged improvements over the years, including paving and roadside development. U.S. Route 150 between Vincennes, Indiana, and Louisville, Kentucky, follows a portion of this path. Sections of the improved Trace have been designated as part of a National Scenic Byway that crosses southern Indiana.
The Trace was created by millions of migrating bison that were numerous in the region from the Great Lakes to Tennessee. It was part of a greater buffalo migration route that extended from present-day Big Bone Lick State Park in Kentucky, through Bullitt's Lick, south of present-day Louisville, and across the Falls of the Ohio River to Indiana, then northwest to Vincennes, before crossing the Wabash River into Illinois. The trail was well known among the area's natives and used for centuries. It later became known and used by European traders and white settlers who crossed the Ohio River at the Falls and followed the Trace overland to the western territories. It is considered to be the most important of the early traces leading to the Illinois country.