Brain-specific angiogenesis inhibitor 1

ADGRB1
Identifiers
Aliases	ADGRB1, BAI1, GDAIF, adhesion G protein-coupled receptor B1
External IDs	MGI: 1933736 HomoloGene: 1287 GeneCards: ADGRB1
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • transmembrane signaling receptor activity • lipopolysaccharide binding • phosphatidylserine binding • receptor activity • PDZ domain binding Cellular component • integral component of membrane • integral component of plasma membrane • cell-cell junction • membrane • phagocytic cup • extracellular space • plasma membrane • focal adhesion • postsynaptic density of dendrite • dendrite • perinuclear region of cytoplasm Biological process • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • cell adhesion • peripheral nervous system development • axonogenesis • signal transduction • negative regulation of cell proliferation • positive regulation of synapse assembly • phagocytosis, recognition • phagocytosis, engulfment • negative regulation of endothelial cell migration • negative regulation of angiogenesis • negative regulation of protein ubiquitination • negative regulation of protein catabolic process • apoptotic cell clearance • engulfment of apoptotic cell • regulation of synaptic plasticity • defense response to Gram-negative bacterium • positive regulation of myoblast fusion • positive regulation of reactive oxygen species biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	575	107831
Ensembl	ENSG00000181790	ENSMUSG00000034730
UniProt	O14514	Q3UHD1
RefSeq (mRNA)	NM_001702	NM_174991
RefSeq (protein)	NP_001693	NP_778156
Location (UCSC)	Chr 8: 142.45 – 142.55 Mb	Chr 15: 74.52 – 74.59 Mb
PubMed search

575

107831

ENSG00000181790

ENSMUSG00000034730

O14514

Q3UHD1

NM_001702

NM_174991

NP_001693

NP_778156

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene. It is a member of the adhesion-GPCR family of receptors.

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

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