BAI3

ADGRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DLO
Identifiers
Aliases	ADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDs	MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3
Gene ontology Molecular function • G-protein coupled receptor activity • protein binding • transmembrane signaling receptor activity • signal transducer activity • GTPase activator activity Cellular component • integral component of membrane • plasma membrane • membrane • postsynapse • synaptic cleft Biological process • negative regulation of angiogenesis • G-protein coupled receptor signaling pathway • positive regulation of GTPase activity • cell surface receptor signaling pathway • myoblast fusion • signal transduction • positive regulation of synapse assembly • regulation of dendrite morphogenesis • motor learning • maintenance of synapse structure • neuron remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	577	210933
Ensembl	ENSG00000135298	ENSMUSG00000033569
UniProt	O60242	Q80ZF8
RefSeq (mRNA)	NM_001704	NM_175642
RefSeq (protein)	NP_001695	NP_783573
Location (UCSC)	Chr 6: 68.64 – 69.39 Mb	Chr 1: 25.07 – 25.83 Mb
PubMed search

4DLO

577

210933

ENSG00000135298

ENSMUSG00000033569

O60242

Q80ZF8

NM_001704

NM_175642

NP_001695

NP_783573

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain. BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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