"Blue Blood Blues" is the second single to be taken from the album Sea of Cowards by the alternative rock group the Dead Weather. It was released digitally on June 25, 2010.

In Elle magazine, the song was named one of 10 "essential" songs produced by Jack White.NME listed the single as one of 20 "unspeakably exciting" songs by White. NME and Rolling Stone pointed out the song's emphatic guitar work based on "Jack Lawrence's grunting fuzz bass [and] Dean Fertita's abrasive skidding guitar".Spin said the guitar runs were "Sabbath-worthy", referring to the hard rock of Black Sabbath. White's vocals were seen to bury those of singer Alison Mosshart.Antiquiet observed that the song was unusual for the Dead Weather in that it felt like a solo piece featuring White.

The song was featured briefly in the E4 comedy-drama television series Misfits in Episode 2, Season 2. It also was played in the closing credits of the Showtime series United States of Tara, in Episode 3, Season 3.

The video for "Blue Blood Blues" premiered on teamcoco.com, the official website of Jack White's friend Conan O'Brien, on June 24, 2010. The recording is an edited live performance from May 3, 2010, at Third Man Records. The style of the video is high contrast solarized black & white, similar to the video for "Fried My Little Brains" by the Kills, the other band of Dead Weather singer Alison Mosshart.

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