"Die by the Drop" is the first single from The Dead Weather's second album Sea of Cowards. It was released on March 30, 2010 in the United States and April 25 in the UK. The single includes the B-side "Old Mary".

The video of the song was directed by Floria Sigismondi who also directed the videos for "Blue Orchid" by The White Stripes and "Broken Boy Soldier" by The Raconteurs, Jack White's other two bands. It is the band's first official video to show all of the Dead Weather members playing their instruments. Footage from the video was used in teaser trailers for the bands upcoming singles, "Blue Blood Blues", "Gasoline" and "Jawbreaker".

John Sakamoto for the Toronto Star said the song "sounds like it should weigh a tonne," with "relentless guitar riffs, throbbing drums, an insistent, plinking piano part, and very loud vocals by White and Alison Mosshart, who don't so much duet as shout at each other."

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