Bisoprolol

Bisoprolol

Clinical data
Trade names	Zebeta, Concor, others
AHFS/Drugs.com	Monograph
MedlinePlus	a693024
License data	US FDA: Bisoprolol
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	by mouth
ATC code	C07AB07 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	>90%
Protein binding	30%
Metabolism	50% liver, CYP2D6, CYP3A4
Biological half-life	10–12 hours
Identifiers
IUPAC name (RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}- 3-(isopropylamino)propan-2-ol
CAS Number	66722-44-9 Y
PubChem CID	2405
IUPHAR/BPS	7129
DrugBank	DB00612 Y
ChemSpider	2312 Y
UNII	Y41JS2NL6U
KEGG	D02342 Y
ChEBI	CHEBI:3127 Y
ChEMBL	CHEMBL645 Y
ECHA InfoCard	100.108.941
Chemical and physical data
Formula	C18H31NO4
Molar mass	325.443 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
SMILES O(c1ccc(cc1)COCCOC(C)C)CC(O)CNC(C)C
InChI InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3 Y Key:VHYCDWMUTMEGQY-UHFFFAOYSA-N Y

Bisoprolol, marketed under the tradename Zebeta among others, is a medication most commonly used for heart diseases. This specifically includes high blood pressure, chest pain from not enough blood flow to the heart, and heart failure. It is taken by mouth.

Common side effects include headache, feeling tired, diarrhea, and swelling in the legs. More severe side effects include worsening asthma, blocking the ability to recognize low blood sugar, and worsening heart failure. There are concerns that use during pregnancy may be harmful to the baby. Bisoprolol is in the Beta blocker family of medications and is of the β₁ selective type.

Bisoprolol was patented in 1976 and approved for medical use in 1986. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Bisoprolol is available as a generic medication. The wholesale cost in the developing world is about 2.98 to 4.94 USD per month. In the United States, as of 2015, it costs about 25 to 50 USD a month.

Bisoprolol is beneficial in treatment for high blood pressure (hypertension), reduced blood flow to the heart (cardiac ischemia); congestive heart failure, and preventive treatment before and primary treatment after heart attacks, decreasing the chances of recurrence. Bisoprolol targets hypertension (elevated blood pressure). In cardiac ischemia, the drug is used to reduce the activity of the heart muscle, so reduces oxygen and nutrient demand, and reduced blood supply can still transport sufficient amounts of oxygen and nutrients.