BioGRID
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| Content | |
| Description | BioGRID is an online biological interaction repository with data compiled through comprehensive curation efforts. |
| Data types captured |
Protein Interactions, Genetic Interactions, Chemical Interactions, Post-Translational Modifications. |
| Organisms | All |
| Contact | |
| Research center | Université de Montréal, Princeton University, Mount Sinai Hospital, University of Edinburgh |
| Laboratory | Institut de Recherche en Immunologie et en Cancérologie, Lewis-Sigler Institute for Integrative Genomics, Lunenfeld-Tanenbaum Research Institute, Wellcome Trust Center for Cell Biology |
| Authors | Lorrie Boucher, Ashton Breitkreutz, Bobby-Joe Breitkreutz, Christie Chang, Andrew Chatr-Aryamontri, Kara Dolinski, Sven Heinicke, Nadine Kolas, Lara O'Donnell, Sara Oster, Rose Oughtred, Jennifer Rust, Adnane Sellam, Chris Stark, Jean Tang, Chandra Theesfeld, Mike Tyers. |
| Primary citation | Stark & al. (2006) |
| Access | |
| Data format | Custom flat files, PSI-MI, MITAB |
| Website | thebiogrid |
| Download URL | thebiogrid |
| Web service URL | Yes - |
| Tools | |
| Web | Advanced search, integrated network viewer, custom downloads, bulk retrieval/download |
| Miscellaneous | |
| Versioning | Yes |
| Data release frequency |
Monthly (4 Weeks) |
| Version | 3.4.125; 1 June 2015 |
| Curation policy | Yes - manual; Also focused curation efforts. |
| Bookmarkable entities |
Yes - both individual results and searches, |
The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein interactions, genetic interactions, chemical interactions, and post-translational modifications created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital. It strives to provide a comprehensive curated resource for all major model organism species while attempting to remove redundancy to create a single mapping of data. Users of The BioGRID can search for their protein or publication of interest and retrieve annotation, as well as curated data as reported, by the primary literature and compiled by in house large-scale curation efforts. The BioGRID is hosted in Toronto, Ontario, Canada and Dallas, Texas, United States and is partnered with the Saccharomyces Genome Database. The BioGRID is funded by the BBSRC, NIH, and CIHR. BioGRID is a member of the International Molecular Exchange Consortium (IMEx).
The BioGRID was originally published and released as simply the General Repository for Interaction Datasets but was later renamed to the BioGRID in order to more concisely describe the project, and help distinguish it from several GRID Computing projects with a similar name. Originally separated into organism specific databases, the newest version now provides a unified front end allowing for searches across several organisms simultaneously. The BioGRID was developed initially as a project at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital but has since expanded to include teams at the Institut de Recherche en Immunologie et en Cancérologie at the Université de Montréal, the Lewis-Sigler Institute for Integrative Genomics at Princeton University, and the Wellcome Trust Center for Cell Biology at the University of Edinburgh. The BioGRID's original focus was on curation of binary protein-protein and genetic interactions, but has expanded over several updates to incorporate curated post-translational modification data,chemical interaction data, and complex multi-gene/protein interactions. Moreover, on a monthly basis, the BioGRID continues to expand curated data and also develop and release new tools, data from comprehensive targeted curation projects, and perform targeted scientific analysis.
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