Beta-synuclein

SNCB
Identifiers
Aliases	SNCB, entrez:6620, synuclein beta
External IDs	OMIM: 602569 MGI: 1889011 HomoloGene: 2320 GeneCards: SNCB
Gene ontology Molecular function • phospholipase inhibitor activity • calcium ion binding • transition metal ion binding • cuprous ion binding Cellular component • inclusion body • synapse • mitochondrion • cytoplasm • cytosol Biological process • negative regulation of neuron apoptotic process • synapse organization • dopamine metabolic process • chemical synaptic transmission • negative regulation of catalytic activity • response to metal ion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6620	104069
Ensembl	ENSG00000074317	ENSMUSG00000034891
UniProt	Q16143	Q91ZZ3
RefSeq (mRNA)	NM_001001502 NM_003085 NM_001318034 NM_001318035 NM_001318036 NM_001318037	NM_033610
RefSeq (protein)	NP_001001502 NP_001304963 NP_001304964 NP_001304965 NP_001304966 NP_003076	NP_291088.1 NP_291088
Location (UCSC)	Chr 5: 176.62 – 176.63 Mb	Chr 13: 54.76 – 54.77 Mb
PubMed search

6620

104069

ENSG00000074317

ENSMUSG00000034891

Q16143

Q91ZZ3

NM_001318037

NM_033610

NP_003076

NP_291088.1
NP_291088

Beta-synuclein is a protein that in humans is encoded by the SNCB gene.

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.

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