Alpha-synuclein

SNCA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XQ8, 2JN5, 2KKW, 2M55, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29, 4BXL, 4R0U, 4R0W, 4RIK, 4RIL, 4ZNN, 5CRW, 2N0A
Identifiers
Aliases	SNCA, NACP, PARK1, PARK4, PD1, synuclein alpha
External IDs	OMIM: 163890 MGI: 1277151 HomoloGene: 293 GeneCards: SNCA
Genetically Related Diseases
Parkinson's disease
Gene ontology Molecular function • calcium ion binding • phospholipase binding • protein domain specific binding • protein N-terminus binding • transcription regulatory region DNA binding • ferrous iron binding • phospholipid binding • metal ion binding • fatty acid binding • enzyme binding • oxidoreductase activity • magnesium ion binding • histone binding • zinc ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • kinesin binding • tau protein binding • copper ion binding • microtubule binding • alpha-tubulin binding • phosphoprotein binding • phospholipase D inhibitor activity • beta-tubulin binding • identical protein binding • dynein complex binding Cellular component • postsynapse • cytoplasm • cytosol • membrane • synapse • extracellular region • mitochondrion • actin cytoskeleton • perinuclear region of cytoplasm • cytoskeleton • nucleus • rough endoplasmic reticulum • ribosome • synaptic vesicle • mitochondrial respiratory chain complex I • platelet alpha granule membrane • terminal bouton • lysosome • Golgi apparatus • intracellular membrane-bounded organelle • growth cone • plasma membrane • axon • cell cortex • inclusion body • nuclear outer membrane • axon terminus • cell junction • cytoplasmic vesicle membrane • extracellular space • supramolecular fiber • neuronal cell body Biological process • negative regulation of neuron apoptotic process • negative regulation of norepinephrine uptake • response to interleukin-1 • response to interferon-gamma • regulation of glutamate secretion • response to magnesium ion • synaptic transmission, dopaminergic • regulation of reactive oxygen species biosynthetic process • positive regulation of protein serine/threonine kinase activity • cellular response to epinephrine stimulus • positive regulation of synaptic transmission • cellular response to copper ion • regulation of synaptic vesicle recycling • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to cocaine • positive regulation of glutathione peroxidase activity • negative regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of serotonin uptake • regulation of dopamine secretion • regulation of long-term neuronal synaptic plasticity • response to iron(II) ion • behavioral response to cocaine • regulation of locomotion • adult locomotory behavior • positive regulation of neurotransmitter secretion • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-serine phosphorylation • regulation of acyl-CoA biosynthetic process • positive regulation of endocytosis • synaptic vesicle endocytosis • excitatory postsynaptic potential • regulation of neuronal synaptic plasticity • mitochondrial membrane organization • negative regulation of mitochondrial electron transport, NADH to ubiquinone • negative regulation of neuron death • chemical synaptic transmission • negative regulation of protein phosphorylation • negative regulation of exocytosis • positive regulation of hydrogen peroxide catabolic process • negative regulation of microtubule polymerization • calcium ion homeostasis • mitochondrial ATP synthesis coupled electron transport • positive regulation of inositol phosphate biosynthetic process • dopamine biosynthetic process • synapse organization • negative regulation of dopamine metabolic process • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of apoptotic process • regulation of reactive oxygen species metabolic process • regulation of neurotransmitter secretion • negative regulation of dopamine uptake involved in synaptic transmission • negative regulation of transcription from RNA polymerase II promoter • microglial cell activation • dopamine uptake involved in synaptic transmission • response to lipopolysaccharide • protein destabilization • neutral lipid metabolic process • negative regulation of thrombin-activated receptor signaling pathway • membrane organization • negative regulation of transporter activity • cellular protein metabolic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of phospholipase activity • negative regulation of chaperone-mediated autophagy • aging • receptor internalization • negative regulation of monooxygenase activity • fatty acid metabolic process • dopamine metabolic process • regulation of neuron death • positive regulation of apoptotic process • synaptic vesicle transport • cellular response to oxidative stress • phospholipid metabolic process • negative regulation of histone acetylation • oxidation-reduction process • response to drug • regulation of macrophage activation • positive regulation of receptor recycling • long-term synaptic potentiation • apoptotic process • supramolecular fiber organization • regulation of presynapse assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6622	20617
Ensembl	ENSG00000145335	ENSMUSG00000025889
UniProt	P37840	O55042
RefSeq (mRNA)	NM_000345 NM_001146054 NM_001146055 NM_007308	NM_001042451 NM_009221
RefSeq (protein)	NP_000336 NP_001139526 NP_001139527 NP_009292	NP_001035916.1 NP_033247.1 NP_001035916 NP_033247
Location (UCSC)	Chr 4: 89.72 – 89.84 Mb	Chr 6: 60.73 – 60.83 Mb
PubMed search

1XQ8, 2JN5, 2KKW, 2M55, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29, 4BXL, 4R0U, 4R0W, 4RIK, 4RIL, 4ZNN, 5CRW, 2N0A

6622

20617

ENSG00000145335

ENSMUSG00000025889

P37840

O55042

...
Wikipedia