Anionic form of α-D-glucose 1-phosphate
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Neutral form of α-D-glucose 1-phosphate
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Names | |
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IUPAC name
Glucose 1-phosphate
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Other names
Cori ester
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Identifiers | |
59-56-3 | |
3D model (Jmol) | Interactive image |
ChEBI | CHEBI:16077 |
ChemSpider | 388311 |
ECHA InfoCard | 100.000.396 |
MeSH | glucose-1-phosphate |
PubChem | 65533 |
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Properties | |
C6H13O9P | |
Molar mass | 260.13 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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what is ?) | (|
Infobox references | |
Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon. It can exist in either the α- or β-anomeric form.
In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure.
To be utilized in cellular catabolism it must first be converted to glucose 6-phosphate by the enzyme phosphoglucomutase. One reason that cells form glucose 1-phosphate instead of glucose during glycogen breakdown is that the very polar phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism.
In glycogenesis, free glucose 1-phosphate can also react with UTP to form UDP-glucose, by using the enzyme UDP-glucose pyrophosphorylase. It can then return to the greater glycogen structure via glycogen synthase.
β-Glucose 1-phosphate is found in some microbes. It is produced by inverting α-glucan phosphorylases including maltose phosphorylase, kojibiose phosphorylase and trehalose phosphorylase and is then converted into glucose 6-phosphate by β-phosphoglucomutase.