The Berlin–Palermo railway axis (German: Eisenbahnachse Berlin–Palermo) is project No. 1 of the Trans-European high-speed rail network (TEN-R), which involves the creation of a 2,200-kilometre-long (1,400 mi) high-speed rail line between Berlin and Palermo. It is designated as one of the main transport links connecting Central and Southern Europe, tracking through Germany, Austria and Italy.
From Berlin the line will run to the Central German Metropolitan Region of Halle/Leipzig, to Erfurt and to Southern Germany at Nuremberg, Ingolstadt and Munich. Crossing the border with Austria, it will continue through the state of Tyrol along Kufstein, Wörgl and the capital Innsbruck. It will enter Italian South Tyrol, passing Franzensfeste and Bolzano, run through Northeast Italy via Verona and Bologna, through Central Italy along Florence and Rome, and reach Southern Italy at Naples and finally shall ferry over to Messina and Palermo on Sicily.