Bendamustine

Bendamustine
Clinical data

Trade names	Treanda, Treakisym, Ribomustin, Levact, others
AHFS/Drugs.com	Monograph
MedlinePlus	a608034
License data	US FDA: Treanda
Pregnancy category	US: D (Evidence of risk)
Routes of administration	intravenous infusion
ATC code	L01AA09 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	NA (intravenous only)
Protein binding	94–96%
Metabolism	Hydrolyzed to inactive metabolites. Two minor metabolites (M3 and M4) formed by CYP1A2
Biological half-life	40 min (bendamustine), 3 h (M3), 30 min (M4)
Excretion	~50% urinary, ~25% fecal
Identifiers
IUPAC name 4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
Synonyms	SDX-105
CAS Number	16506-27-7^Y
PubChem (CID)	65628
IUPHAR/BPS	7478
ChemSpider	59069^Y
UNII	9266D9P3PQ^Y
ChEMBL	CHEMBL487253^Y
ECHA InfoCard	100.205.789
Chemical and physical data
Formula	C₁₆H₂₁Cl₂N₃O₂
Molar mass	358.262 g/mol
3D model (Jmol)	Interactive image
SMILES ClCCN(c2ccc1c(nc(n1C)CCCC(=O)O)c2)CCCl
InChI InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)^Y Key:YTKUWDBFDASYHO-UHFFFAOYSA-N^Y

Bendamustine, sold under the brand name Treanda among others, is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. It is given by injection into a vein.

Common side effects include low blood cell counts, fever, nausea, diarrhea, loss of appetite, cough, and rash. Other severe side effects include allergic reactions and increased risk of infection. Use in pregnancy is known to harm the baby. Bendamustine is in the alkylating agents family of medication. It works by interfering with the function of DNA and RNA.

Bendamustine was approved for medical use in the United States in 2008. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The cost in the United Kingdom for the NHS is 275.81 pounds per 100 mg vial. It was originally made from nitrogen mustard.

Bendamustine has been used both as sole therapy and in combination with other agents including etoposide, fludarabine, mitoxantrone, methotrexate, prednisone, rituximab, vincristine and ⁹⁰Y-ibritumomab tiuxetan.

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