BRAF (gene)

BRAF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UWH, 1UWJ, 2FB8, 2L05, 3C4C, 3D4Q, 3IDP, 3II5, 3NY5, 3OG7, 3PPJ, 3PPK, 3PRF, 3PRI, 3PSB, 3PSD, 3Q4C, 3Q96, 3SKC, 3TV4, 3TV6, 4DBN, 4E26, 4E4X, 4EHE, 4EHG, 4FC0, 4FK3, 4G9C, 4G9R, 4H58, 4JVG, 4KSP, 4KSQ, 4MBJ, 4MNE, 4MNF, 4PP7, 4WO5, 5C9C, 5CT7, 4XV2, 4XV1, 4XV9, 4XV3, 4R5Y, 5CSW, 5CSX, 4YHT, 5J2R, 5FD2, 5HIE, 5HID, 5HI2, 4CQE, 5J18
Identifiers
Aliases	BRAF, B-RAF1, BRAF1, NS7, RAFB1, B-Raf, B-Raf proto-oncogene, serine/threonine kinase
External IDs	MGI: 88190 HomoloGene: 3197 GeneCards: BRAF
Targeted by Drug
dabrafenib, regorafenib, sorafenib, vemurafenib
Gene ontology Molecular function • protein kinase activity • calcium ion binding • nucleotide binding • signal transducer activity, downstream of receptor • transferase activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • small GTPase binding • protein binding • identical protein binding • protein heterodimerization activity • ATP binding • MAP kinase kinase kinase activity • mitogen-activated protein kinase kinase binding Cellular component • cell body • intracellular membrane-bounded organelle • membrane • mitochondrion • neuron projection • nucleus • intracellular • cytoplasm • cytosol • plasma membrane Biological process • visual learning • negative regulation of neuron apoptotic process • cellular response to calcium ion • CD4-positive, alpha-beta T cell differentiation • negative regulation of endothelial cell apoptotic process • negative regulation of fibroblast migration • intracellular signal transduction • head morphogenesis • myeloid progenitor cell differentiation • somatic stem cell population maintenance • protein heterooligomerization • phosphorylation • thymus development • establishment of protein localization to membrane • response to peptide hormone • negative regulation of apoptotic process • positive regulation of axon regeneration • positive T cell selection • positive regulation of axonogenesis • positive regulation of peptidyl-serine phosphorylation • MAPK cascade • negative regulation of synaptic vesicle exocytosis • protein phosphorylation • positive regulation of substrate adhesion-dependent cell spreading • thyroid gland development • cellular response to drug • positive regulation of gene expression • face development • regulation of cell proliferation • regulation of axon regeneration • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • alpha-beta T cell differentiation • response to cAMP • positive regulation of stress fiber assembly • glucose transport • signal transduction • long-term synaptic potentiation • activation of MAPKK activity • negative regulation of signal transduction • cell differentiation • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment • regulation of T cell differentiation • T cell receptor signaling pathway • cellular response to nerve growth factor stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	673	109880
Ensembl	ENSG00000157764	ENSMUSG00000002413
UniProt	P15056	P28028
RefSeq (mRNA)	NM_004333	NM_139294
RefSeq (protein)	NP_004324	NP_647455.3 NP_647455
Location (UCSC)	Chr 7: 140.72 – 140.92 Mb	Chr 6: 39.6 – 39.73 Mb
PubMed search

1UWH, 1UWJ, 2FB8, 2L05, 3C4C, 3D4Q, 3IDP, 3II5, 3NY5, 3OG7, 3PPJ, 3PPK, 3PRF, 3PRI, 3PSB, 3PSD, 3Q4C, 3Q96, 3SKC, 3TV4, 3TV6, 4DBN, 4E26, 4E4X, 4EHE, 4EHG, 4FC0, 4FK3, 4G9C, 4G9R, 4H58, 4JVG, 4KSP, 4KSQ, 4MBJ, 4MNE, 4MNF, 4PP7, 4WO5, 5C9C, 5CT7, 4XV2, 4XV1, 4XV9, 4XV3, 4R5Y, 5CSW, 5CSX, 4YHT, 5J2R, 5FD2, 5HIE, 5HID, 5HI2, 4CQE, 5J18

...
Wikipedia