BMP5

BMP5
Identifiers
Aliases	BMP5, entrez:653
External IDs	OMIM: 112265 MGI: 88181 HomoloGene: 22412 GeneCards: BMP5
Gene ontology Molecular function • cytokine activity • BMP receptor binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • extracellular region • extracellular space • vesicle Biological process • regulation of apoptotic process • pattern specification process • skeletal system development • cell differentiation • male genitalia development • regulation of MAPK cascade • SMAD protein signal transduction • ossification • positive regulation of epithelial cell proliferation • negative regulation of mononuclear cell migration • negative regulation of cortisol biosynthetic process • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of dendrite development • positive regulation of DNA-dependent DNA replication • BMP signaling pathway • multicellular organism development • cartilage development • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of insulin-like growth factor receptor signaling pathway • type B pancreatic cell development • negative regulation of steroid biosynthetic process • negative regulation of epithelial to mesenchymal transition • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of aldosterone biosynthetic process • endocardial cushion formation • pericardium morphogenesis • neural fold elevation formation • hindbrain development • cardiac muscle tissue development • pharyngeal system development • cardiac septum morphogenesis • chorio-allantoic fusion • heart trabecula morphogenesis • allantois development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	653	12160
Ensembl	ENSG00000112175	ENSMUSG00000032179
UniProt	P22003	P49003
RefSeq (mRNA)	NM_021073 NM_001329754 NM_001329756	NM_007555
RefSeq (protein)	NP_001316683 NP_001316685 NP_066551 NP_066551.1	NP_031581.2 NP_031581
Location (UCSC)	Chr 6: 55.75 – 55.88 Mb	Chr 9: 75.78 – 75.9 Mb
PubMed search

653

12160

ENSG00000112175

ENSMUSG00000032179

P22003

P49003

NM_021073
NM_001329754
NM_001329756

NM_007555

NP_001316683
NP_001316685
NP_066551
NP_066551.1

NP_031581.2
NP_031581

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

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Wikipedia