Noggin (protein)

NOG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M4U
Identifiers
Aliases	NOG, Nog, SYM1, SYNS1, SYNS1A, noggin
External IDs	MGI: 104327 HomoloGene: 3979 GeneCards: NOG
Gene ontology Molecular function • protein homodimerization activity • protein binding • cytokine binding Cellular component • extracellular region • extracellular space Biological process • positive regulation of glomerulus development • pattern specification process • axial mesoderm development • skeletal system development • cell differentiation • ureteric bud development • negative regulation of astrocyte differentiation • pituitary gland development • positive regulation of branching involved in ureteric bud morphogenesis • lung morphogenesis • negative regulation of cartilage development • somatic stem cell population maintenance • fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation • positive regulation of epithelial cell proliferation • negative regulation of cytokine activity • neural plate morphogenesis • negative regulation of cell differentiation • anatomical structure formation involved in morphogenesis • mesoderm formation • negative regulation of apoptotic signaling pathway • embryonic digit morphogenesis • cellular response to BMP stimulus • wound healing • in utero embryonic development • BMP signaling pathway • negative regulation of gene expression • somite development • negative regulation of osteoblast differentiation • embryonic skeletal system development • nervous system development • axon guidance • negative regulation of BMP signaling pathway • regulation of BMP signaling pathway • multicellular organism development • prostatic bud formation • limb development • central nervous system development • cartilage development • neural tube closure • brain development • negative regulation of cell migration • notochord morphogenesis • cell differentiation in hindbrain • mesenchymal cell differentiation • regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation • neural tube development • spinal cord development • ureteric bud formation • epithelial to mesenchymal transition • middle ear morphogenesis • embryonic skeletal joint morphogenesis • urogenital system development • endoderm formation • negative regulation of cardiac muscle cell proliferation • motor neuron axon guidance • dorsal/ventral pattern formation • negative regulation of canonical Wnt signaling pathway • face morphogenesis • positive regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • osteoblast differentiation • membranous septum morphogenesis • outflow tract morphogenesis • endocardial cushion morphogenesis • ventricular compact myocardium morphogenesis • endoderm development • positive regulation of gene expression • atrial cardiac muscle tissue morphogenesis • negative regulation of pathway-restricted SMAD protein phosphorylation • ventricular septum morphogenesis • BMP signaling pathway involved in heart development • heart trabecula morphogenesis • pharyngeal arch artery morphogenesis • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9241	18121
Ensembl	ENSG00000183691	ENSMUSG00000048616
UniProt	Q13253	P97466
RefSeq (mRNA)	NM_005450	NM_008711
RefSeq (protein)	NP_005441	NP_032737.1 NP_032737
Location (UCSC)	Chr 17: 56.59 – 56.6 Mb	Chr 11: 89.3 – 89.3 Mb
PubMed search

1M4U

9241

18121

ENSG00000183691

ENSMUSG00000048616

Q13253

P97466

NM_005450

NM_008711

NP_005441

NP_032737.1
NP_032737

Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. In humans is encoded by the NOG gene. The amino acid sequence of human noggin is highly homologous to that of rat, mouse, and Xenopus (an aquatic-frog genus).

The protein's name, which is a slang English-language word for "head," was coined in reference to its ability to produce embryos with large heads when exposed at high concentrations.

Noggin is a signaling molecule that plays an important role in promoting somite patterning in the developing embryo. It is released from the and regulates bone morphogenic protein during development. The absence of BMP4 will cause the patterning of the neural tube and somites from the neural plate in the developing embryo. It also causes formation of the head and other dorsal structures.

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