BMI1

BMI1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2H0D, 3RPG, 4R8P
Identifiers
Aliases	BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
External IDs	HomoloGene: 136787 GeneCards: BMI1
Gene ontology Molecular function • promoter-specific chromatin binding • RING-like zinc finger domain binding • metal ion binding • protein binding • zinc ion binding Cellular component • cytoplasm • ubiquitin ligase complex • nucleoplasm • PRC1 complex • PcG protein complex • nucleus • cytosol • nuclear body Biological process • hemopoiesis • regulation of transcription, DNA-templated • positive regulation of fibroblast proliferation • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • segment specification • negative regulation of gene expression, epigenetic • positive regulation of ubiquitin-protein transferase activity • regulation of gene expression • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	648	n/a
Ensembl	ENSG00000168283	n/a
UniProt	P35226 Q5T8Z6	n/a
RefSeq (mRNA)	NM_005180	n/a
RefSeq (protein)	NP_001190991 NP_005171	n/a
Location (UCSC)	Chr 10: 22.32 – 22.33 Mb	n/a
PubMed search		n/a

2H0D, 3RPG, 4R8P

648

n/a

ENSG00000168283

n/a

P35226
Q5T8Z6

n/a

NM_005180

n/a

NP_001190991
NP_005171

n/a

Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.

BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. Bmi1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Recently it has been reported BMI1 is rapidly recruited to sites of DNA damage and it sustains for over than 8h. Loss of BMI1 leads to radiation sensitive and impaired repair of DNA double-strand breaks by homologous recombination 10.

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