CDKN2D

CDKN2D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BD8, 1BI8
Identifiers
Aliases	CDKN2D, INK4D, p19, p19-INK4D, cyclin-dependent kinase inhibitor 2D, cyclin dependent kinase inhibitor 2D
External IDs	MGI: 105387 HomoloGene: 36081 GeneCards: CDKN2D
Gene ontology Molecular function • protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding Cellular component • cytoplasm • nucleoplasm • nucleus • cytosol • cyclin D2-CDK4 complex Biological process • DNA synthesis involved in DNA repair • regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to vitamin D • response to retinoic acid • G1/S transition of mitotic cell cycle • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • negative regulation of cell growth • cell cycle arrest • cell cycle • negative regulation of phosphorylation • response to UV • autophagic cell death • negative regulation of cell proliferation • negative regulation of protein serine/threonine kinase activity • sensory perception of sound • negative regulation of cell cycle G1/S phase transition Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1032	12581
Ensembl	ENSG00000129355	ENSMUSG00000096472
UniProt	P55273	Q60773
RefSeq (mRNA)	NM_079421 NM_001800	NM_009878
RefSeq (protein)	NP_001791 NP_524145	NP_034008
Location (UCSC)	Chr 19: 10.57 – 10.57 Mb	Chr 9: 21.29 – 21.29 Mb
PubMed search

1BD8, 1BI8

1032

12581

ENSG00000129355

ENSMUSG00000096472

P55273

Q60773

NM_079421
NM_001800

NM_009878

NP_001791
NP_524145

NP_034008

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

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