BCR gene

BCR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K1F, 2AIN
Identifiers
Aliases	BCR, Bcr, 5133400C09Rik, AI561783, AI853148, mKIAA3017, ALL, BCR1, CML, D22S11, D22S662, PHL, RhoGEF and GTPase activating protein, BCR gene
External IDs	MGI: 88141 HomoloGene: 3192 GeneCards: BCR
Genetically Related Diseases
smallpox
Gene ontology Molecular function • transferase activity • nucleotide binding • guanyl-nucleotide exchange factor activity • kinase activity • protein serine/threonine kinase activity • protein binding • Rho guanyl-nucleotide exchange factor activity • enzyme binding • protein tyrosine kinase activity • ATP binding • GTPase activator activity Cellular component • cytoplasm • cytosol • postsynaptic membrane • membrane • postsynaptic density • plasma membrane • synapse • protein complex • cell junction • extracellular exosome • intracellular Biological process • positive regulation of phagocytosis • intracellular signal transduction • neuromuscular process controlling balance • phosphorylation • regulation of cell cycle • negative regulation of blood vessel remodeling • protein phosphorylation • negative regulation of cellular extravasation • response to lipopolysaccharide • brain development • regulation of vascular permeability • negative regulation of cell migration • negative regulation of neutrophil degranulation • inner ear morphogenesis • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • negative regulation of inflammatory response • actin cytoskeleton organization • signal transduction • peptidyl-tyrosine phosphorylation • renal system process • homeostasis of number of cells • regulation of nitrogen compound metabolic process • definitive hemopoiesis • negative regulation of respiratory burst • intracellular protein transmembrane transport • cellular response to lipopolysaccharide • negative regulation of reactive oxygen species metabolic process • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	613	110279
Ensembl	ENSG00000186716	ENSMUSG00000009681
UniProt	P11274	Q6PAJ1
RefSeq (mRNA)	NM_004327 NM_021574	NM_001081412
RefSeq (protein)	NP_004318 NP_067585	NP_001074881.1 NP_001074881
Location (UCSC)	Chr 22: 23.18 – 23.32 Mb	Chr 10: 75.06 – 75.18 Mb
PubMed search

Bcr-Abl oncoprotein oligomerisation domain
structure of the bcr-abl oncoprotein oligomerization domain
Identifiers
Symbol	Bcr-Abl_Oligo
Pfam	PF09036
InterPro	IPR015123
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1K1F, 2AIN

613

110279

ENSG00000186716

ENSMUSG00000009681

P11274

Q6PAJ1

NM_004327
NM_021574

NM_001081412

NP_004318
NP_067585

NP_001074881.1
NP_001074881

The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL complex, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.

Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for RAC1 and CDC42.