BCAM

BCAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PET, 2PF6
Identifiers
Aliases	BCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group)
External IDs	MGI: 1929940 HomoloGene: 21149 GeneCards: BCAM
Gene ontology Molecular function • laminin receptor activity • protein C-terminus binding • protein binding • laminin binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • cell surface • plasma membrane • integral component of plasma membrane • extracellular exosome • membrane • external side of plasma membrane Biological process • cell adhesion • cell-matrix adhesion • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4059	57278
Ensembl	ENSG00000187244	ENSMUSG00000002980
UniProt	P50895	Q9R069
RefSeq (mRNA)	NM_005581 NM_001013257	NM_020486
RefSeq (protein)	NP_001013275 NP_005572	NP_065232.1 NP_065232
Location (UCSC)	Chr 19: 44.81 – 44.82 Mb	Chr 7: 19.76 – 19.77 Mb
PubMed search

2PET, 2PF6

4059

57278

ENSG00000187244

ENSMUSG00000002980

P50895

Q9R069

NM_005581
NM_001013257

NM_020486

NP_001013275
NP_005572

NP_065232.1
NP_065232

Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 (cluster of differentiation 239).

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.

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