BARD1

BARD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JM7, 2NTE, 2R1Z, 3C5R, 3FA2
Identifiers
Aliases	BARD1, BRCA1 associated RING domain 1
External IDs	MGI: 1328361 HomoloGene: 400 GeneCards: BARD1
Gene ontology Molecular function • metal ion binding • protein homodimerization activity • kinase binding • RNA binding • protein heterodimerization activity • ubiquitin-protein transferase activity • protein binding • transferase activity Cellular component • cytoplasm • BRCA1-A complex • BRCA1-BARD1 complex • ubiquitin ligase complex • nucleus • P-body • nucleoplasm • nuclear speck Biological process • regulation of phosphorylation • negative regulation of apoptotic process • protein K6-linked ubiquitination • negative regulation of mRNA 3'-end processing • positive regulation of protein catabolic process • negative regulation of protein export from nucleus • cell cycle arrest • double-strand break repair via nonhomologous end joining • cellular response to DNA damage stimulus • tissue homeostasis • protein ubiquitination • positive regulation of apoptotic process • DNA replication • DNA double-strand break processing • DNA synthesis involved in DNA repair • regulation of signal transduction by p53 class mediator • DNA repair • strand displacement • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	580	12021
Ensembl	ENSG00000138376	ENSMUSG00000026196
UniProt	Q99728	O70445
RefSeq (mRNA)	NM_000465 NM_001282543 NM_001282545 NM_001282548 NM_001282549	NM_007525
RefSeq (protein)	NP_000456 NP_001269472 NP_001269474 NP_001269477 NP_001269478 NP_001269474.1	NP_031551
Location (UCSC)	Chr 2: 214.73 – 214.81 Mb	Chr 1: 71.03 – 71.1 Mb
PubMed search

1JM7, 2NTE, 2R1Z, 3C5R, 3FA2

580

12021

ENSG00000138376

ENSMUSG00000026196

Q99728

O70445

NM_000465
NM_001282543
NM_001282545
NM_001282548
NM_001282549

NM_007525

NP_001269474.1

NP_031551

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and two tandem BRCT domains (residues 568-777).

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