Augustine Grimaldi (1482 – 14 April 1532) was Regent of Monaco (1523–1532), Bishop of Grasse, Abbot of Lérins, and founder of the village of Valbonne.
Augustine was the son of Lambert Grimaldi, Lord of Monaco (1420–1494) and Claudine Grimaldi (1451–1515). Two of his brothers, Jean (1468–1505) and Lucien (1487–1523) were Lords of Monaco.
Upon the assassination of his brother Lucien on 22 August 1523, Augustine was appointed Regent to Lucien's son Honoré, who was not yet a year old. He held this position for over 8 years, until his death at the age of 50 in 1532.
In 1524, to better avenge himself on his brother's murderers, Bartholomew Doria and Andrea Doria, Augustine deserted Francis I of France, with whom the Doria's were allied. He then swore allegiance to Charles V, Holy Roman Emperor and King of Spain, by the signing of the Treaties of Burgos and Tordesillas. This brought Monaco under Spanish protection, and Augustine was placed at the head of the government in Monaco. The alliance lasted from 1525 to 1641. This alliance weighed heavily on the financial situation of Monaco, and shortly before his death, Augustine admitted to regret for his actions in this regard.