Arylsulfatase E

ARSE

Identifiers

ARSE, ASE, CDPX, CDPX1, CDPXR, arylsulfatase E (chondrodysplasia punctata 1)

External IDs

Gene ontology
Molecular function	• sulfuric ester hydrolase activity • catalytic activity • hydrolase activity • arylsulfatase activity • metal ion binding
Cellular component	• Golgi stack • endoplasmic reticulum lumen • extracellular exosome • Golgi apparatus • membrane • integral component of membrane
Biological process	• post-translational protein modification • skeletal system development • metabolic process • glycosphingolipid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


415


n/a

Ensembl


ENSG00000157399


n/a

UniProt


P51690


n/a

RefSeq (mRNA)


NM_000047 NM_001282628 NM_001282631


n/a

RefSeq (protein)


NP_000038 NP_001269557 NP_001269560 NP_001269557.1 NP_001269560.1


n/a

Location (UCSC)

Chr X: 2.93 – 2.97 Mb

n/a

PubMed search

n/a

415

n/a

ENSG00000157399

n/a

P51690

n/a

NM_000047
NM_001282628
NM_001282631

n/a

NP_000038
NP_001269557
NP_001269560
NP_001269557.1
NP_001269560.1

n/a

Arylsulfatase E, also known as ARSE, is an enzyme that, in humans, is encoded by the ARSE gene.

Arylsulfatase E is a member of the arylsulfatase subfamily of sulfatase enzymes that catalyze the hydrolysis of sulfate esters. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix.

Deficiencies in ARSE are associated with X-linked recessive chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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