Aryl hydrocarbon receptor

AHR
Identifiers
Aliases	AHR, bHLHe76, aryl hydrocarbon receptor, Aryl hydrocarbon receptor
External IDs	OMIM: 600253 MGI: 105043 HomoloGene: 1224 GeneCards: AHR
Gene ontology Molecular function • DNA binding • Hsp90 protein binding • protein dimerization activity • aryl hydrocarbon receptor activity • transcription factor binding • enhancer binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • E-box binding • protein binding • protein heterodimerization activity • transcription regulatory region DNA binding • transcription factor activity, sequence-specific DNA binding • TFIID-class transcription factor binding • transcription coactivator binding • TBP-class protein binding Cellular component • cytoplasm • transcription factor complex • cytosolic aryl hydrocarbon receptor complex • nuclear aryl hydrocarbon receptor complex • nucleus • aryl hydrocarbon receptor complex • nucleoplasm • cytosol • protein complex Biological process • regulation of transcription, DNA-templated • rhythmic process • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • circadian regulation of gene expression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of B cell proliferation • blood vessel development • regulation of gene expression • xenobiotic metabolic process • cell cycle • negative regulation of transcription, DNA-templated • response to toxic substance • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • intracellular receptor signaling pathway • response to xenobiotic stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	196	11622
Ensembl	ENSG00000106546	ENSMUSG00000019256
UniProt	P35869	P30561
RefSeq (mRNA)	NM_001621	NM_013464 NM_001314027
RefSeq (protein)	NP_001612	NP_038492.1 NP_001300956 NP_038492
Location (UCSC)	Chr 7: 17.3 – 17.35 Mb	Chr 12: 35.5 – 35.54 Mb
PubMed search

196

11622

ENSG00000106546

ENSMUSG00000019256

P35869

P30561

NM_001621

NM_013464
NM_001314027

NP_001612

NP_038492.1
NP_001300956
NP_038492

The aryl hydrocarbon receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as .

The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors. AHR binds several exogenous ligands such as natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

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Wikipedia