Elections were held on November 2, 2010, to determine Missouri's nine members of the United States House of Representatives. Representatives were elected for two-year terms to serve in the 112th Congress from January 3, 2011 until January 3, 2013. Primary elections were held on August 3, 2010.
Of the nine elections, the races in the 3rd and 4th districts were rated as competitive by The Cook Political Report,CQ Politics,The Rothenberg Political Report and Sabato's Crystal Ball. Seven of Missouri's nine incumbents were re-elected, while one (Ike Skelton of the 4th district) unsuccessfully sought re-election and one (Roy Blunt of the 7th district) did not seek re-election.
In total, six Republicans and three Democrats were elected. A total of 1,920,675 votes were cast, of which 1,103,290 (57.44 percent) were for Republican candidates, 708,064 (36.87 percent) were for Democratic candidates, 92,485 (4.81 percent) were for Libertarian Party candidates, 8,759 (0.46 percent) were for Constitution Party candidates, 7,193 (0.37 percent) were for an independent candidate and 884 (0.05 percent) were for write-in candidates.