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Apolipoprotein B100

APOB
Identifiers
Aliases APOB, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B
External IDs OMIM: 107730 MGI: 88052 HomoloGene: 328 GeneCards: APOB
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)
Chromosome 2 (human)
Genomic location for APOB
Genomic location for APOB
Band 2p24.1 Start 21,001,429 bp
End 21,044,073 bp
RNA expression pattern
PBB GE APOB 205108 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000384

NM_009693

RefSeq (protein)

NP_000375

NP_033823

Location (UCSC) Chr 2: 21 – 21.04 Mb Chr 2: 7.98 – 8.02 Mb
PubMed search

NM_000384

NM_009693

NP_000375

NP_033823

Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene.

Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, IDL, and LDL particles (LDL - known commonly by the misnomer "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body (within the water outside cells) to all cells within all tissues. While all the functional roles of ApoB within the LDL (and all larger) particles remains somewhat unclear, it is the primary organizing protein (of the entire complex shell enclosing/carrying fat molecules within) component of the particles and is absolutely required for the formation of these particles. What is also clear is that the ApoB on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body (i.e., less formally, ApoB indicates fat carrying particles are ready to enter any cells with ApoB receptors and deliver fats carried within into the cells).


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Wikipedia

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