The term "pogrom" in the meaning of large-scale, targeted, and repeated anti-Jewish rioting, saw its first use in the 19th century, in reference to the anti-Jewish pogroms in the Russian Empire. Pogroms began occurring after the Russian Empire, which previously had very few Jews, acquired territories with large Jewish populations during 1791-1835. These territories were designated "the Pale of Settlement" by the Russian government, within which Jews were reluctantly permitted to live, and it was within them that the pogroms largely took place. Most Jews were forbidden from moving to other parts of the Empire, unless they converted to the Russian Orthodox state religion.
The first pogrom is sometimes considered to be the 1821 Odessa pogroms after the execution of the Greek Orthodox patriarch Gregory V in Constantinople, in which 14 Jews were killed. The initiators of the 1821 pogroms were the local Greeks, who used to have a substantial diaspora in the port cities of what was known as Novorossiya. Some sources consider the first pogrom to be the 1859 riots in Odessa.
The term "pogrom" became commonly used in English after a large-scale wave of anti-Jewish riots swept through south-western Imperial Russia (present-day Ukraine and Poland) from 1881 to 1884 (in that period over 200 anti-Jewish events occurred in the Russian Empire, notably the Kiev, Warsaw and Odessa pogroms).
The trigger for these pogroms was the assassination of Tsar Alexander II, for which some blamed "the Jews". The extent to which the Russian press was responsible for encouraging perceptions of the assassination as a Jewish act has been disputed. Local economic conditions (such as ancestral debts owed to moneylenders) are thought to have contributed significantly to the rioting, especially with regard to the participation of the business competitors of local Jews and the participation of railroad workers. It has been argued that this was actually more important than rumours of Jewish responsibility for the death of the Tsar. These rumours, however, were clearly of some importance, if only as a trigger, and they drew upon a small kernel of truth: one of the close associates of the assassins, Gesya Gelfman, was born into a Jewish home. The fact that the other assassins were all atheists and that the wider Jewish community had nothing to do with the assassination had little impact on the spread of such antisemitic rumours. Nonetheless, the assassination inspired "retaliatory" attacks on Jewish communities. During these pogroms thousands of Jewish homes were destroyed, many families were reduced to poverty, and large numbers of men, women, and children were injured in 166 towns in the southwest provinces of the Empire such as Ukraine.