Anoctamin 1

ANO1
Identifiers
Aliases	ANO1, DOG1, ORAOV2, TAOS2, TMEM16A, anoctamin 1
External IDs	MGI: 2142149 HomoloGene: 75079 GeneCards: ANO1
Gene ontology Molecular function • calcium activated cation channel activity • protein dimerization activity • protein binding • voltage-gated chloride channel activity • chloride channel activity • iodide transmembrane transporter activity • intracellular calcium activated chloride channel activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • chloride channel complex • apical plasma membrane • extracellular exosome Biological process • cation transport • ion transport • detection of temperature stimulus involved in sensory perception of pain • multicellular organism development • phospholipase C-activating G-protein coupled receptor signaling pathway • ion transmembrane transport • iodide transport • chloride transport • cation transmembrane transport • regulation of anion transmembrane transport • cellular response to heat • positive regulation of insulin secretion involved in cellular response to glucose stimulus • chloride transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55107	101772
Ensembl	ENSG00000131620	ENSMUSG00000031075
UniProt	Q5XXA6	Q8BHY3
RefSeq (mRNA)	NM_018043	NM_001242349 NM_178642
RefSeq (protein)	NP_060513	NP_001229278 NP_848757
Location (UCSC)	Chr 11: 70.08 – 70.19 Mb	Chr 7: 144.59 – 144.75 Mb
PubMed search

55107

101772

ENSG00000131620

ENSMUSG00000031075

Q5XXA6

Q8BHY3

NM_018043

NM_001242349
NM_178642

NP_060513

NP_001229278
NP_848757

Anoctamin-1 (ANO1) also known as Transmembrane member 16A (TMEM16A) is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-sensitive calcium-activated chloride channel that is expressed in smooth muscle and epithelial cells; it is highly expressed in human interstitial cells of Cajal (ICC) throughout the gastrointestinal tract. Changes in ANO1 channel activity directly/positively correlate with ICC activity.

ANO1 is a transmembrane protein that functions as a calcium-activated chloride channel.Ca²⁺, Sr²⁺, and Ba²⁺ activate the channel.

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