Calcium-activated chloride channel | |||||||||
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Identifiers | |||||||||
Symbol | CLCA_N | ||||||||
Pfam | PF08434 | ||||||||
InterPro | IPR013642 | ||||||||
TCDB | 1.A.17 | ||||||||
OPM superfamily | 517 | ||||||||
OPM protein | 4wis | ||||||||
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Available protein structures: | |
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Pfam | structures |
PDB | RCSB PDB; PDBe; PDBj |
PDBsum | structure summary |
The calcium-activated chloride channels (CaCCs), are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory (CLCA),bestrophin (BEST), and anoctamin (ANO or TMEM16) channelsANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.
CaCCs that are known to occur in humans include:
Secrete chloride into lumen
This article incorporates text from the public domain Pfam and InterPro IPR013642