Angiomotin-like protein 1

AMOTL1
Identifiers
Aliases	AMOTL1, JEAP, angiomotin like 1
External IDs	MGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Gene location (Human) Chr. Chromosome 11 (human) Band n/a Start 94,706,431 bp End 94,876,753 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band n/a Start 14,541,966 bp End 14,645,056 bp
Gene ontology Molecular function • protein binding • identical protein binding Cellular component • COP9 signalosome • cytosol • apical plasma membrane • cytoplasmic vesicle • lamellipodium • bicellular tight junction • cell junction Biological process • establishment of cell polarity involved in ameboidal cell migration • Wnt signaling pathway • hippo signaling • positive regulation of blood vessel endothelial cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	154810	75723
Ensembl	ENSG00000166025	ENSMUSG00000013076
UniProt	Q8IY63	Q9D4H4
RefSeq (mRNA)	NM_001301007 NM_130847	NM_001081395
RefSeq (protein)	NP_001287936 NP_570899 NP_570899.1	NP_001074864
Location (UCSC)	Chr 11: 94.71 – 94.88 Mb	Chr 11: 14.54 – 14.65 Mb
PubMed search

154810

75723

ENSG00000166025

ENSMUSG00000013076

Q8IY63

Q9D4H4

NM_001301007
NM_130847

NM_001081395

NP_001287936
NP_570899
NP_570899.1

NP_001074864

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.

...
Wikipedia