Angiomotin

AMOT
Identifiers
Aliases	AMOT, angiomotin
External IDs	MGI: 108440 HomoloGene: 15778 GeneCards: AMOT
Gene ontology Molecular function • protein binding • receptor activity • angiostatin binding Cellular component • cytoplasm • integral component of membrane • cytosol • ruffle • endocytic vesicle • stress fiber • cell surface • cell junction • actin filament • COP9 signalosome • cytoplasmic vesicle • external side of plasma membrane • lamellipodium • bicellular tight junction Biological process • regulation of cell migration • blood vessel morphogenesis • blood vessel endothelial cell migration • gastrulation with mouth forming second • in utero embryonic development • hippo signaling • vasculogenesis • establishment of cell polarity involved in ameboidal cell migration • chemotaxis • negative regulation of GTPase activity • positive regulation of blood vessel endothelial cell migration • cell-cell junction assembly • positive regulation of cell size • negative regulation of angiogenesis • cell migration involved in gastrulation • positive regulation of embryonic development • regulation of small GTPase mediated signal transduction • positive regulation of stress fiber assembly • negative regulation of vascular permeability • actin cytoskeleton organization • cellular protein localization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	154796	27494
Ensembl	ENSG00000126016	ENSMUSG00000041688
UniProt	Q4VCS5	Q8VHG2
RefSeq (mRNA)	NM_001113490 NM_133265	NM_001290274 NM_153319
RefSeq (protein)	NP_001106962 NP_573572	NP_001277203 NP_695231
Location (UCSC)	Chr X: 112.77 – 112.84 Mb	Chr X: 145.45 – 145.51 Mb
PubMed search

154796

27494

ENSG00000126016

ENSMUSG00000041688

Q4VCS5

Q8VHG2

NM_001113490
NM_133265

NM_001290274
NM_153319

NP_001106962
NP_573572

NP_001277203
NP_695231

Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene. It belongs to the motin family of angiostatin binding proteins, which includes angiomotin, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2) characterized by coiled-coil domains at N-terminus and consensus PDZ-binding domain at the C-terminus. Angiomotin is expressed predominantly in endothelial cells of capillaries as well as angiogenic tissues such as placenta and solid tumor.

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