Angela Brodie
| Angela Hartley Brodie | |
|---|---|
| Born | Angela Hartley 28 September 1934 Manchester, England |
| Fields | Cancer research |
| Institutions | Worcester Foundation for Experimental Biology |
| Known for | Development of first aromatase inhibitors |
| Spouse | Harry Brodie |
| Children | 2, including John H. Brodie |
Angela Hartley Brodie (born 28 September 1934) is a British cancer researcher who pioneered development of steroidal aromatase inhibitors. Born in Manchester in 1934, Brodie went on to study chemical pathology to a doctoral level and was awarded a fellowship sponsored by National Institutes of Health. After some time working on oral contraceptives with the Harry Brodie, whom she married, she switched focus to the effects of the estrogen-producing enzyme, aromatase, on breast cancer.
Brodie managed to get an aromatase inhibitor into a limited clinical trial in London, which had such a profound effect that it led to Novartis-sponsored trials. She was behind the development of formestane, the first aromatase inhibitor used on breast cancer patients, marketed in 1994. Brodie's work has been hailed "as among the most important contributions to cancer cure."
Brodie was born Angela Hartley on 28 September 1934 in Manchester, England. Her father, Herbert Hartley, was an organic chemist working in polyurethanes who inspired her interest in science. Brodie was educated at a Quaker boarding school before studying at University of Sheffield, where she earned a degree in Biochemistry. After leaving university, she took a job in a blood bank before finding a laboratory position as a research assistant in Department of Hormone Research at Manchester's Christie Cancer Hospital Whilst there, she concentrated on estrogen-dependent breast cancer for two years before joining the University of Manchester to study for her doctorate.
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