Afdera (Afar Afxeera) is one of the woredas in the Afar Region of Ethiopia. It is named after the saline Lake Afdera, located in the southern part of the Afar Depression. Part of the Administrative Zone 2, Afdera is bordered on the southwest by the Administrative Zone 4, on the west by Erebti and Abala, on the north by Berhale, on the northeast by Eritrea, and on the southeast by Administrative Zone 1. The largest towns of this woreda is Afdera.
The highest peak in Afdera is Mount Mallahle (1875 meters); other mountains in this woreda include Erta Ale and Borawli. Mining is the principal industry in this woreda. The best known resource extracted is salt; according to the Afar Regional Mining and Energy Office, there are 300 active land grants around Lake Afdera, which the Office reports creates 1,800 permanent and over 40,000 part-time jobs.
An all-weather road constructed in the 1990s connects this woreda to the main Awash - Asseb highway. About 90 kilometers of this gravel road, connecting Afdera to Serdo, was completed in late January 2009 at a cost of 387 million Birr. A spokesman for the Ethiopian Roads Authority stated that since it links with the port in Djibouti City, the upgraded road would have great significance for tourism and import-export trade exchange.