Addressin

MADCAM1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9
Identifiers
Aliases	MADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDs	GeneCards: MADCAM1
Gene ontology Molecular function • integrin binding involved in cell-matrix adhesion Cellular component • integral component of membrane • plasma membrane • membrane Biological process • leukocyte tethering or rolling • integrin-mediated signaling pathway • heterotypic cell-cell adhesion • aging • cell adhesion • cell-matrix adhesion • extracellular matrix organization • receptor clustering • immune response • signal transduction • positive regulation of leukocyte migration • regulation of immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8174	n/a
Ensembl	ENSG00000099866	n/a
UniProt	Q13477	n/a
RefSeq (mRNA)	NM_130762 NM_130760	n/a
RefSeq (protein)	NP_570116 NP_570118	n/a
Location (UCSC)	Chr 19: 0.49 – 0.51 Mb	n/a
PubMed search		n/a

1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9

8174

n/a

ENSG00000099866

n/a

Q13477

n/a

NM_130762
NM_130760

n/a

NP_570116
NP_570118

n/a

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.

Addressin is an extracellular protein of the endothelium of venules.

Addressins are the ligands to the homing receptors of lymphocytes. The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

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Wikipedia