Acetyl-CoA C-acyltransferase

HADHB
Identifiers
Aliases	HADHB, ECHB, MSTP029, MTPB, TP-BETA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
External IDs	OMIM: 143450 MGI: 2136381 HomoloGene: 153 GeneCards: HADHB
Gene ontology Molecular function • transferase activity • transferase activity, transferring acyl groups other than amino-acyl groups • enoyl-CoA hydratase activity • long-chain-3-hydroxyacyl-CoA dehydrogenase activity • protein binding • catalytic activity • transferase activity, transferring acyl groups • 3-hydroxyacyl-CoA dehydrogenase activity • RNA binding • acetyl-CoA C-acyltransferase activity Cellular component • membrane • mitochondrial outer membrane • endoplasmic reticulum • mitochondrial inner membrane • mitochondrial envelope • mitochondrial nucleoid • extracellular exosome • mitochondrion Biological process • lipid metabolic process • fatty acid metabolic process • metabolic process • cardiolipin acyl-chain remodeling • fatty acid beta-oxidation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3032	231086
Ensembl	ENSG00000138029	ENSMUSG00000059447
UniProt	P55084	Q99JY0
RefSeq (mRNA)	NM_000183 NM_001281512 NM_001281513	NM_145558 NM_001289798 NM_001289799
RefSeq (protein)	NP_000174 NP_001268441 NP_001268442	NP_001276727.1 NP_001276728.1 NP_663533.1 NP_001276727 NP_001276728 NP_663533
Location (UCSC)	Chr 2: 26.24 – 26.29 Mb	Chr 5: 30.16 – 30.18 Mb
PubMed search

3032

231086

ENSG00000138029

ENSMUSG00000059447

P55084

Q99JY0

NM_000183
NM_001281512
NM_001281513

NM_145558
NM_001289798
NM_001289799

NP_000174
NP_001268441
NP_001268442

NP_663533

Trifunctional enzyme subunit beta, mitochondrial (TP-beta) also known as 3-ketoacyl-CoA thiolase, acetyl-CoA acyltransferase, or beta-ketothiolase is an enzyme that in humans is encoded by the HADHB gene.

HADHB is a subunit of the and has thiolase activity.

The HADHB gene is located on chromosome 2, with its specific location being 2p23. The gene contains 17 exons. HADHB encodes a 51.2 kDa protein that is composed of 474 amino acids; 124 peptides have been observed through mass spectrometry data.

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