Acaçá

ACACA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YL2, 3COJ, 4ASI
Identifiers
Aliases	ACACA, ACAC, ACACAD, ACC, ACC1, ACCA, acetyl-CoA carboxylase alpha
External IDs	MGI: 108451 HomoloGene: 31015 GeneCards: ACACA
Gene ontology Molecular function • nucleotide binding • acetyl-CoA carboxylase activity • metal ion binding • biotin carboxylase activity • ligase activity • protein binding • catalytic activity • ATP binding Cellular component • mitochondrion • actin cytoskeleton • extracellular exosome • fibrillar center • cytoplasm • cytosol Biological process • carnitine shuttle • malonyl-CoA biosynthetic process • biotin metabolic process • lipid metabolic process • fatty acid metabolic process • cellular response to prostaglandin E stimulus • fatty acid biosynthetic process • long-chain fatty-acyl-CoA biosynthetic process • tissue homeostasis • acetyl-CoA metabolic process • lipid homeostasis • metabolic process • multicellular organismal protein metabolic process • positive regulation of cellular metabolic process • protein homotetramerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	31	107476
Ensembl	n/a	ENSMUSG00000020532
UniProt	Q13085	Q5SWU9
RefSeq (mRNA)	NM_000664 NM_198834 NM_198835 NM_198836 NM_198837 NM_198838 NM_198839	NM_133360
RefSeq (protein)	NP_942131 NP_942133 NP_942134 NP_942135 NP_942136	NP_579938.2 NP_579938
Location (UCSC)	Chr 17: 37.08 – 37.41 Mb	Chr 11: 84.13 – 84.4 Mb
PubMed search

2YL2, 3COJ, 4ASI

31

107476

n/a

ENSMUSG00000020532

Q13085

Q5SWU9

NM_198838
NM_198839

NM_133360

NP_942131
NP_942133
NP_942134
NP_942135
NP_942136

NP_579938.2
NP_579938

Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene.

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.

...
Wikipedia