A proliferation-inducing ligand

TNFSF13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZCH
Identifiers
Aliases	TNFSF13, APRIL, CD256, TALL-2, TALL2, TRDL-1, ZTNF2, UNQ383/PRO715, TNLG7B, tumor necrosis factor superfamily member 13, TNF superfamily member 13
External IDs	MGI: 1916833 HomoloGene: 56971 GeneCards: TNFSF13
Gene location (Human) Chr. Chromosome 17 (human) Band n/a Start 7,558,292 bp End 7,561,608 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 69,682,846 bp End 69,685,784 bp
Gene ontology Molecular function • receptor binding • tumor necrosis factor receptor binding • cytokine activity Cellular component • cytosol • membrane • nucleoplasm • cytoplasm • extracellular exosome • extracellular region • extracellular space Biological process • tumor necrosis factor-mediated signaling pathway • regulation of mRNA stability • positive regulation of cell proliferation • immune system process • signal transduction • positive regulation of isotype switching to IgA isotypes • immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8741	69583
Ensembl	ENSG00000161955	ENSMUSG00000089669
UniProt	O75888	Q9D777
RefSeq (mRNA)	NM_001198622 NM_001198623 NM_001198624 NM_003808 NM_172087 NM_172088	NM_001159505 NM_023517
RefSeq (protein)	NP_001185551 NP_001185552 NP_001185553 NP_003799 NP_742084 NP_742085	NP_001152977 NP_076006
Location (UCSC)	Chr 17: 7.56 – 7.56 Mb	Chr 17: 69.68 – 69.69 Mb
PubMed search

4ZCH

8741

69583

ENSG00000161955

ENSMUSG00000089669

O75888

Q9D777

NM_172088

NM_001159505
NM_023517

NP_742085

NP_001152977
NP_076006

A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI.

In the cluster of differentiation terminology, APRIL is designated CD256.

The protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL have normal immune system development. However, APRIL-deficient mice have also been reported to possess a reduced ability to support plasma cell survival. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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