TNFRSF14

TNFRSF14
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1JMA, 2AW2, 4FHQ, 4RSU
Identifiers
Aliases	TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, tumor necrosis factor receptor superfamily member 14
External IDs	MGI: 2675303 HomoloGene: 2833 GeneCards: TNFRSF14
Gene ontology Molecular function • virus receptor activity • protein binding • tumor necrosis factor-activated receptor activity • ubiquitin protein ligase binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane Biological process • regulation of apoptotic process • T cell costimulation • tumor necrosis factor-mediated signaling pathway • multicellular organism development • cell surface receptor signaling pathway • response to lipopolysaccharide • negative regulation of alpha-beta T cell proliferation • regulation of cell proliferation • defense response to Gram-negative bacterium • immune response • positive regulation of cytokine secretion involved in immune response • positive regulation of peptidyl-tyrosine phosphorylation • apoptotic signaling pathway • viral entry into host cell • inflammatory response • viral process • positive regulation of T cell migration • defense response to Gram-positive bacterium Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8764	230979
Ensembl	n/a	ENSMUSG00000042333
UniProt	Q92956	n/a
RefSeq (mRNA)	NM_001297605 NM_003820	NM_178931
RefSeq (protein)	NP_001284534 NP_003811	n/a
Location (UCSC)	Chr 1: 2.56 – 2.57 Mb	Chr 4: 154.92 – 154.93 Mb
PubMed search

1JMA, 2AW2, 4FHQ, 4RSU

8764

230979

n/a

ENSMUSG00000042333

Q92956

n/a

NM_001297605
NM_003820

NM_178931

NP_001284534
NP_003811

n/a

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily.

This protein was originally known as herpesvirus entry mediator A (HveA); HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. It is also known as CD270 in the cluster of differentiation classification. Moreover, it is also referred to as ATAR (another TRAF-associated receptor).

...
Wikipedia