ATG4B

ATG4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CY7, 2D1I, 2Z0D, 2Z0E, 2ZZP
Identifiers
Aliases	ATG4B, APG4B, AUTL1, autophagy related 4B cysteine peptidase
External IDs	MGI: 1913865 HomoloGene: 100868 GeneCards: ATG4B
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.3 Start 241,637,213 bp End 241,673,857 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 93,751,500 bp End 93,790,610 bp
Gene ontology Molecular function • peptidase activity • cysteine-type peptidase activity • endopeptidase activity • protein binding • hydrolase activity • cysteine-type endopeptidase activity Cellular component • cytoplasm • cytosol Biological process • autophagy • protein transport • autophagy of nucleus • C-terminal protein lipidation • positive regulation of protein catabolic process • autophagy of mitochondrion • autophagosome assembly • macroautophagy • proteolysis • protein targeting to membrane • protein delipidation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23192	66615
Ensembl	ENSG00000168397	ENSMUSG00000026280
UniProt	Q9Y4P1	Q8BGE6
RefSeq (mRNA)	NM_013325 NM_178326	NM_174874
RefSeq (protein)	NP_037457 NP_847896	NP_777363
Location (UCSC)	Chr 2: 241.64 – 241.67 Mb	Chr 2: 93.75 – 93.79 Mb
PubMed search

2CY7, 2D1I, 2Z0D, 2Z0E, 2ZZP

23192

66615

ENSG00000168397

ENSMUSG00000026280

Q9Y4P1

Q8BGE6

NM_013325
NM_178326

NM_174874

NP_037457
NP_847896

NP_777363

Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene.

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. One main function of Atg4 is to cleave the pre-protein of Atg8, leading to the non-lapidated soluble (-I) form which can be processed further by Atg3, Atg7, Atg5-12 into the lipidated form (-II) anchored to the autophagic membrane.

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Wikipedia