ATG12

ATG12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GDK, 4GDL, 4NAW
Identifiers
Aliases	ATG12, APG12, APG12L, FBR93, HAPG12, autophagy related 12
External IDs	MGI: 1914776 HomoloGene: 37953 GeneCards: ATG12
Gene ontology Molecular function • protein binding • Atg8 ligase activity Cellular component • cytoplasm • cytosol • pre-autophagosomal structure membrane • phagocytic vesicle membrane • Atg12-Atg5-Atg16 complex • membrane • protein complex • autophagosome Biological process • autophagy • nucleophagy • C-terminal protein lipidation • mitophagy • macroautophagy • autophagosome assembly • immune system process • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9140	67526
Ensembl	ENSG00000145782	ENSMUSG00000032905
UniProt	O94817	Q9CQY1
RefSeq (mRNA)	NM_001277783 NM_004707	NM_026217
RefSeq (protein)	NP_001264712 NP_004698	NP_080493
Location (UCSC)	Chr 5: 115.83 – 115.84 Mb	Chr 18: 46.73 – 46.74 Mb
PubMed search

4GDK, 4GDL, 4NAW

9140

67526

ENSG00000145782

ENSMUSG00000032905

O94817

Q9CQY1

NM_001277783
NM_004707

NM_026217

NP_001264712
NP_004698

NP_080493

Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene.

Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998).[supplied by OMIM]

Autophagy requires the covalent attachment of the protein Atg12 to ATG5 through a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine.

...
Wikipedia