ATF2

ATF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BHI, 1T2K, 4H36
Identifiers
Aliases	ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7, activating transcription factor 2
External IDs	MGI: 109349 HomoloGene: 31061 GeneCards: ATF2
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 175,072,250 bp End 175,168,382 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C3 Start 73,816,509 bp End 73,892,639 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • cAMP response element binding protein binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription coactivator activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • chromatin binding • metal ion binding • RNA polymerase II activating transcription factor binding • transcription factor activity, RNA polymerase II transcription factor binding • protein binding • enhancer sequence-specific DNA binding • protein heterodimerization activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein kinase binding • cAMP response element binding • histone acetyltransferase activity Cellular component • cytoplasm • membrane • nucleoplasm • mitochondrial outer membrane • mitochondrion • nucleus • site of double-strand break Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • intra-S DNA damage checkpoint • outflow tract morphogenesis • response to water deprivation • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • positive regulation of transforming growth factor beta2 production • transcription, DNA-templated • cellular response to DNA damage stimulus • response to osmotic stress • positive regulation of neuron apoptotic process • regulation of sequence-specific DNA binding transcription factor activity • positive regulation of mitochondrial membrane permeability involved in apoptotic process • negative regulation of epithelial cell proliferation • adipose tissue development • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • amelogenesis • histone acetylation • positive regulation of cardiac muscle myoblast proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1386	11909
Ensembl	ENSG00000115966	ENSMUSG00000027104
UniProt	P15336	P16951
RefSeq (mRNA)	NM_001256090 NM_001256091 NM_001256092 NM_001256093 NM_001256094 NM_001880	NM_001025093 NM_001284369 NM_001284370 NM_001284371 NM_001284372 NM_001284373 NM_001284374 NM_001284376 NM_009715
RefSeq (protein)	NP_001243019 NP_001243020 NP_001243021 NP_001243022 NP_001243023 NP_001871	NP_001020264 NP_001271298 NP_001271299 NP_001271300 NP_001271301 NP_001271302 NP_001271303 NP_001271305 NP_033845
Location (UCSC)	Chr 2: 175.07 – 175.17 Mb	Chr 2: 73.82 – 73.89 Mb
PubMed search

1BHI, 1T2K, 4H36

1386

11909

ENSG00000115966

ENSMUSG00000027104

P15336

P16951

NM_001880

NM_001284373
NM_001284374
NM_001284376
NM_009715

NP_001871

NP_001271302
NP_001271303
NP_001271305
NP_033845

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.

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