ARNTL

ARNTL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H10
Identifiers
Aliases	ARNTL, BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5, aryl hydrocarbon receptor nuclear translocator like
External IDs	MGI: 1096381 HomoloGene: 910 GeneCards: ARNTL
Genetically Related Diseases
schizophrenia
Gene ontology Molecular function • DNA binding • Hsp90 protein binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • aryl hydrocarbon receptor binding • protein binding • repressing transcription factor binding • transcription regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • core promoter sequence-specific DNA binding • core promoter binding • transcriptional activator activity, RNA polymerase II transcription factor binding • bHLH transcription factor binding • sequence-specific DNA binding • protein heterodimerization activity • E-box binding Cellular component • cytoplasm • PML body • intracellular membrane-bounded organelle • transcription factor complex • nucleoplasm • nucleus • nuclear body • chromatoid body Biological process • regulation of transcription, DNA-templated • rhythmic process • transcription, DNA-templated • regulation of hair cycle • protein import into nucleus, translocation • transcription from RNA polymerase II promoter • spermatogenesis • circadian rhythm • negative regulation of TOR signaling • circadian regulation of gene expression • regulation of protein catabolic process • positive regulation of circadian rhythm • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of fat cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • regulation of neurogenesis • regulation of insulin secretion • regulation of cell cycle • response to redox state • maternal process involved in parturition • positive regulation of canonical Wnt signaling pathway • oxidative stress-induced premature senescence • regulation of type B pancreatic cell development • negative regulation of glucocorticoid receptor signaling pathway • regulation of cellular senescence • positive regulation of skeletal muscle cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	406	11865
Ensembl	ENSG00000133794	ENSMUSG00000055116
UniProt	O00327	Q9WTL8
RefSeq (mRNA)	NM_001030272 NM_001030273 NM_001178 NM_001297719 NM_001297722 NM_001297724	NM_001243048 NM_007489
RefSeq (protein)	NP_001025443 NP_001025444 NP_001169 NP_001284648 NP_001284651 NP_001284653	NP_001229977.1 NP_031515.1 NP_001229977 NP_031515
Location (UCSC)	Chr 11: 13.28 – 13.39 Mb	Chr 7: 113.21 – 113.31 Mb
PubMed search

4H10

406

11865

ENSG00000133794

ENSMUSG00000055116

O00327

Q9WTL8

NM_001297724

NM_001243048
NM_007489

NP_001284653

NP_001229977.1
NP_031515.1
NP_001229977
NP_031515

Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene also known as Bmal, Mop3, TIC, JAP3, PASD3, Bmal1c, bHLHe5.

ARNTL encodes for a transcription factor with a basic helix-loop-helix (bHLH) and a PAS domain. The human ARNTL gene has a predicted 24 exons and is located on the p15 band of the 11th chromosome. The BMAL1 protein is 626 amino acids long and plays a key role as one of the positive elements in the mammalian autoregulatory transcription translation negative feedback loop (TTFL), which is responsible for generating molecular circadian rhythms. BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns. BMAL1, according to genome-wide profiling, is estimated to target more than 150 sites in the human genome, including all of the clock genes and genes encoding for proteins that regulate metabolism.

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